Researchers studying whether botulinum neurotoxin (BoNT) A, BoNT/D and tetanus toxin (TeNT) can spread within networks of neurons to have distal effects found that indeed they do.
Specifically, they found that while the toxins act on the targeted neurons, they are also taken up, via an alternative pathway, where they are transported and released to exert effects on upstream neurons.
The result, at least in a lab dish, is long-distance effects, according to the study, epublished August 4 in Cell Reports.
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