Dermatologists may need to look further than red hair and freckles when identifying patients who might be genetically predisposed to skin cancer.

A University of Queensland review of the key genes affecting pigmentation could be the first step towards incorporating genomics into clinical practice to identify high-risk patients.

Associate Professor Rick Sturm, from UQโ€™s Dermatology Research Centre, said the review was prompted by the need to provide the latest information to clinicians.

โ€œThe whole idea of how we will deliver medicine in the future is directed towards personal or precision medicine,โ€ Dr Sturm said.

โ€œThis will require clinicians to understand their patientsโ€™ genetic background, so we really needed a primer for the dermatologists on the genes they should know about.โ€

The review gives an overview of 15 genes which affect pigmentation of the skin, eyes and hair or melanoma risk.

โ€œThese include the most important genes for pigment which, when they are mutated, have a manifestation of genetic disease,โ€ Dr Sturm said.

โ€œDermatologists might already have some knowledge of the gene associated with red hair and freckling, which is MC1R, but there are many others.โ€

Dr Sturm said there were now three major genes associated with naevi or moles.

โ€œOne of these genes โ€“ ย IRF4 โ€“ has a big effect on naevi count, and recently itโ€™s been suggested the gene can have a significant effect on the type of melanoma a patient may get,โ€ he said.