Childhood atopic dermatitis subsides by adulthood in most cases; however, clinical factors such as already persistent disease, later onset, and/or more severe disease increases the risk for persistence, according to recent study results.

โ€œAtopic dermatitis (AD)/eczema is a chronic inflammatory skin disease with a clinical course that varies widely between patients,โ€ Jooho P. Kim, BA, of the department of dermatology at Northwestern University Feinberg School of Medicine in Chicago, and colleagues wrote. โ€œSome children have disease activity that persists well into adolescence and adulthood, although most children are thought to โ€˜grow out of it.โ€™ Much of the data to support this notion originate from smaller studies and did not account for a number of clinical factors that might modify disease persistence.โ€

Kim and colleagues conducted a systematic review of 45 studies within multiple existing databases and a meta-analysis using Kaplan-Meier plots and random-effects proportional hazards regression to determine the overall persistence rates of the disease and clinical factors associated with disease persistence.

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