Liquid nose jobs, jawline sculpting, tear trough filler—some of today’s hottest injectable tweaks are actually not sanctioned by the FDA. But over the years, as injectors have grown more familiar with the intricacies and nuances of various fillers, their catalog of “off-label” uses has swelled. Nearly the entire body is now fair game. And savvy patients, keen to this fact, are getting more creative with their asks.

We polled board-certified plastic surgeons and dermatologists for the weirdest off-label requests they’ve willingly (and safely) granted.