The term “anti-aging” has jumped from moisturizer containers and vials of retinol serum to cookbooks and herbal supplements. For these, “anti-aging” is not only a cosmetic effect — smooth skin, clear eyes — but a nutritional strategy that can actually slow the age-related deterioration of the body and brain by fine-tuning our internal molecular process. Or can it?

When it comes to diets, the “anti-aging” label can be misleading — that’s the conclusion of a new, sweeping review article published in the journal Science on Thursday. The review authors call into question the idea that studies done mostly in rodents and non-mammalian subjects can have any implication for human health.

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