Treating severely sun-damaged patients’ individual lesions with cryotherapy alone is unlikely to lead to optimal outcomes. That’s because of a concept called field cancerization, which suggests that cancer does not arise as an isolated cellular phenomenon, but rather as an anaplastic tendency involving many cells simultaneously, according to Anokhi Jambusaria, M.D., M.S.C.E., staff dermatologist, Baylor Scott and White Health, Round Rock, Texas.

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