Delayed hypersensitivity reactions at the site of injection with the Moderna COVID-19 vaccine are possible, but these delayed reactions do not represent a contraindication to secondary vaccination. This is according to findings from a case series study published in JAMA Dermatology.

The case series study included 16 patients referred to Yale New Haven Hospital with localized cutaneous injection site reactions from January to February 2021. The investigators examined demographic data, relevant medical history, and clinical course. In addition to evaluating these data, the researchers also reviewed photographs of 13 patients and histopathologic examination findings for a skin biopsy taken from 1 of the patients.

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