Very low doses of hyaluronidase can remove hyaluronic acid filler nodules, but more rapid resolution is seen with slightly higher doses, according to a study published online April 25 in JAMA Dermatology.

Murad Alam, MD, from Northwestern University in Chicago, and colleagues conducted a randomized clinical trial involving nine healthy women to examine the effectiveness of small quantities of hyaluronidase to treat hyaluronic acid filler nodules.