Patients with photoaged skin reported improvements in both skin texture and wrinkles after a single injection of platelet-rich plasma (PRP) compared with saline (placebo), a parallel, split-face, randomized clinical trial found.

At 6 months post-treatment, participants gave their PRP-injected cheek significantly higher scores over their saline-injected cheek for skin texture (mean [SD] score of 2.00 [1.20] versus 1.21 [0.54], P=0.02) and wrinkles (1.74 [0.99] versus 1.21 [0.54], P=0.03), according to Murad Alam, MD, of Northwestern University Feinberg School of Medicine in Chicago, and colleagues.

But dermatologists who assessed these same patients via photograph found no significant differences at any time point studied (2 weeks, 3 months, 6 months) for the primary outcomes of overall photoaging scores and fine line, mottled pigmentation, and skin roughness and sallowness subscores, they wrote in JAMA Dermatology.

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