Botox injections are approved to reduce the frequency of migraine headaches, but studies of their effectiveness have had mixed results. Now a review of studies has concluded that Botox has small but significant benefits, with few serious side effects.

Researchers analyzed data from 17 studies, including 3,646 patients, that tested botulinum toxin injections against placebos. More than 86 percent of the patients were women, and 43 percent had chronic migraines, with more than 15 headache days a month. The analysis is in Plastic and Reconstructive Surgery.

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