According to a report published in the November issue of Annals of Plastic Surgery, women who receive silicone gel-filled breast implants do not have a higher risk of breast cancer or other cancers and do not experience lower survival rates after breast cancer diagnosis.

The review was led by Joseph McLaughlin, PhD, professor of medicine at Vanderbilt-Ingram Cancer Center and a member of the International Epidemiology Institute (IEI), Rockville, Md, and Loren Lipworth, ScD, associate professor of medicine at Vanderbilt-Ingram and member of IEI. The epidemiologists surveyed the evidence on the safety of breast implants, including numerous large cohort studies with long-term follow-up.

The in-depth review also addressed noncancer outcomes and found no causal association between silicone breast implants and health issues such as connective tissue disease, neurologic disease, or birth defects in children born to women with implants.

“Few implantable medical devices have been investigated for safety hazards more extensively than silicone gel-filled breast implants,” says McLaughlin. “For almost three decades researchers around the world have been conducting in-depth studies on the health of women with implants to determine if there are significant health risks. The evidence is clear that implants are not linked to serious disease.”

Dozens of health risk studies were launched after the FDA banned the use of silicone breast implants in 1992, citing a lack of evidence that the devices were safe. One fear of safety advocates is that the implants interfere with mammography to screen for breast cancer. However McLaughlin, Lipworth, and their colleagues reviewed several studies, which used control groups to provide comparison data, and found that while the sensitivity of mammography may be reduced somewhat by the implants, women with implants in fact do not present with more advanced cases of breast cancer or suffer from lower survival rates after diagnosis with breast cancer, both of which would indicate interference by implants. And there is no evidence that the implants caused higher rates of cancer, regardless of anatomic site.

The only cancer risk cited in any of the incidence studies was a significant increase in lung cancer in a large group of Swedish women with breast implants. However an earlier survey of these same women found that they were 2.8 times more likely to be current smokers than the general female population. Smoking is the primary risk factor for lung cancer.

“We also looked at the risk for brain cancer because of an isolated mortality elevation reported in one study,” says Lipworth. “Further research, based on a number of large-scale incidence surveys with complete follow-up, consistently failed to demonstrate any excess of brain cancer among women with cosmetic breast implants.”

The weight of this evidence and that for noncancer outcomes are among the reasons the FDA lifted its ban on silicone gel-filled breast implants in 2006.

While the researchers found no increased cancer risk or link to autoimmune diseases or birth defects, there is a clear statistical correlation with later suicide risk. Five large epidemiologic mortality studies, including a 2007 study of Swedish women by McLaughlin and Lipworth, found an increase in the suicide rate among women who had undergone breast implant surgery during the period of the 1960s through the early 1990s.

[www.tennessean.com, October 25, 2007]