Periorbital wrinkling is one of the earliest signs of aging and can be one of the most challenging aesthetic regions to treat. This study compares a new technology, TMFI therapy, with non-ablative fractional 1565 nm laser (NAFL) for the treatment of periorbital wrinkling.

The clinical report, led by Fares Salameh, MD, is titled, “Treatment of periorbital wrinkles using thermo-mechanical fractional injury therapy versus fractional non-ablative 1565 nm laser: A comparative prospective, randomized, double-arm, controlled study.” 

This study, published in Lasers in Surgery and Medicine, the official journal of the American Society for Laser Medicine and Surgery Inc, was selected as the December 2021 Editor’s Choice.

Thermo‐mechanical fractional injury therapy (Tixel, Novoxel, Israel) is a new technology that is now being used for facial skin rejuvenation. The Tixel is a non-laser, non-radiofrequency, thermomechanical fractional skin treatment device intended for cutaneous procedures requiring coagulation of soft tissue; it transfers heat to the skin directly without emitting radiation. Such technology offers a user-friendly method for performing fractional skin treatment.

The Tixel device treatment was found to be an effective and safe modality for the treatment of periorbital wrinkling, with comparable results to the 1565 nm laser but less painful.

“Periorbital wrinkles are an early manifestation of photoaging, starting as early as the third decade of life and often distressing to patients, causing them to seek rejuvenation procedures,” Salameh says. “Our study introduces a new effective and safe alternative treatment for this challenging indication.”

[Source: American Society for Laser Medicine and Surgery Inc]